Scientists at the University of California, San Diego have proposed an accurate way to convert the age of dogs into human.
- The simple formula made it possible to derive a comparison of epigenetic time.
|The formula for converting the age of dogs to human.|
A team of geneticists from led by Trey Ideker and Tina Van found a way to do this much more accurately.At UCLA, biologists have developed a new formula for determining the age of dogs. Previously, it was thought that in order to understand how many "human" years a dog, its age simply needs to be multiplied by seven.
However, scientists thought that this calculation could not be considered correct. Comparison should be made through physiological stages: when teeth, puberty, maturity and aging begin to appear.
Researchers based their research on such a factor as methyl groups, which join the DNA without changing it.
We have observed the greatest similarity of methyl when comparing young dogs with young people or older dogs with adults, - say researchers.
As a result, the following formula was developed: human age = 16 ln(dog_age) + 31. Using epigenetics and physiology, the scientists found that a seven-week old puppy corresponds to a child of 9 months in all age characteristics.
At this age, puppies, like children, have teeth that erupt. Signs of old age appear in the Labrador 12 years old, if translated to "human" age, the dog is 70 years old.
- For teenagers and adults, the correlation was more rough: the epigene showed faster changes in dogs than expected in physiological charts," the researchers say.
Converting the age of dogs to humanResearchers selected 104 Labradors, who were from four weeks to sixteen years old. As it turned out, Labrador DNA also accumulates methyl groups over time.
The methylation process in dogs was compared with a similar process in 320 people. It turned out that dogs have genes in which age-related changes in DNA are pronounced, and these genes are common to both humans and animals.
As the authors of the study emphasize, they were able to identify a non-linear relationship, which allowed to accurately correlate the age of animals and humans.
The study was published in www.biorxiv.org.